Find out how Zoloft is used to treat anxiety, its effectiveness, dosage, side effects, and when it may be the right option for you. Find patient medical information for Sertraline (Zoloft) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Sertraline is a medication that increases the amount of serotonin hormone in your brain. It treats depression, anxiety and other mental health conditions. Zoloft is an antidepressant used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, and post-traumatic stress disorder. Description Sertraline is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, premenstrual dysphoric disorder (PMDD), posttraumatic stress disorder (PTSD), and social anxiety disorder (SAD). Sertraline belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). It works by increasing the activity of a chemical called serotonin in the. Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [11] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [12] Sertraline (Zoloft) is an SSRI used to treat depression, anxiety, OCD, PTSD, and PMDD by increasing serotonin levels to improve mood and emotional balance. Zoloft belongs to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). This article describes the dosages of Zoloft, as well as its forms, strengths, and how to take it. See risks & benefits. Learn more about ZOLOFT® (sertraline HCl), a prescription treatment for depression. Sertraline (Zoloft) is a prescription oral tablet that is used to treat depression and other mental health conditions. Learn about sertraline's side effects, dosage, cost, warnings, and more.